Reproductive genome editing interventions are therapeutic, sometimes

In Vivo Delivery Systems for Therapeutic Genome Editing

Therapeutic genome editing technology has been widely used as a powerful tool for directly correcting genetic mutations in target pathological tissues and cells to cure of diseases. The modification of specific genomic sequences can be achieved by utilizing programmable nucleases, such as Meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and ...

The therapeutic potential of genome editing for β-thalassemia.

The rapid advances in the field of genome editing using targeted endonucleases have called considerable attention to the potential of this technology for human gene therapy. Targeted correction of disease-causing mutations could ensure lifelong, tissue-specific expression of the relevant gene, thereby alleviating or resolving a specific disease phenotype. In this review, we aim to explore the p...

The therapeutic landscape of HIV-1 via genome editing

Current treatment for HIV-1 largely relies on chemotherapy through the administration of antiretroviral drugs. While the search for anti-HIV-1 vaccine remain elusive, the use of highly active antiretroviral therapies (HAART) have been far-reaching and has changed HIV-1 into a manageable chronic infection. There is compelling evidence, including several side-effects of ARTs, suggesting that erad...

Sometimes Updates Are Circumscription

Model-based revision of knowledge bases ex­ pressed as first-order theories was shown in [Winslett 88b] to be useful as a means of de­ scribing and reasoning about the effects of ac­ tions. This paper shows that model-based the­ ory revision is actually expressible as a form of circumscription. This shows that in cer­ tain applications, the cumbersome conceptu­ ally machinery of circumscription...

Genome Editing